Newsletters

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in this issue
* Multidimensional Brain & Nervous System Support
* Proper Neuronal Support Is Crucial to Stable Mood & Cognition
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Proper Neuronal Support Is Crucial to Stable Mood & Cognition

According to the National Institutes of Health, 4 to 5 million Americans and Canadians live with mild cognitive impairment (MCI) and Alzhemer’s Disease (AD), while close to 50 million people experience depression. Furthermore, addictions and insomnia are
observed in 20 and 30 million individuals, respectively, in the U.S. and Canada. Since neuronal communication is normally fine-tuned, any deviation in the production, absorption, or reabsorption of
neurochemicals may lead to chemical imbalance that can cause dramatic shifts in physical, cognitive, and mood behaviors. While the exact mechanism of how certain natural ingredients may directly or indirectly influence particular neuronal activities is yet to be
determined, a number of herbal compounds have emerged as promising candidates for neuronal support. One nutritional approach to neurological health may be to focus on 2 critical steps—to restore connection and to restore balance in the brain. More specifically, formulations designed to act centrally—i.e., incorporating ingredients with potential to cross the blood-brain barrier—should further aid in
providing neurological support.

Overall Strategy that Invigorates Brain Health

Restore Connection:

* Improve neuronal communication
* Support neuronal integrity
* Manage substances that interfere with message development and delivery

Restore balance:

* Maintain a healthy relationship between excitatory and inhibitory messages—i.e., neurochemicals such as acetylcholine, gamma-
aminobutyric acid (GABA), glutamate, dopamine, norepinephrine, serotonin, and melatonin—that affect behavior

Five Groups of Natural Ingredients Targeting the Central Nervous System

Cognition & Memory:
Improve acetylcholine function

* Huperzine A
* a-Tocotrienol complex
* 5-Methyl tetrahydrofolate (5-MTHF)

Nervousness:
Improve GABA & glutamate function

* Taurine
* N-Acetylcysteine
* Green tea extract (catechins and EGCG)
* Magnesium and vitamin B6

Focus & Attention:
Improve dopamine & catecholamine function

* Docosahexaenoic acid (DHA)
* Casein tryptic hydrosylate
* L-Theanine

Depression:
Improve cortisol & serotonin function

* Dehydroepiandrosterone (DHEA)
* Vitamin D
* Methylcobalamin
* 5-Methyl tetrahydrofolate (5-MTHF)

Insomnia:
Improve melatonin & sleep hygiene function

* Melatonin
* Casein tryptic hydrosylate
* Passion flower extract

More on Neurological Health, click here.

HealthDesigns.com Newsletter
HDI eNews
Nov 2 2006

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in this issue
* A Natural Approach to Support Memory & Cognition

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A Natural Approach to Support Memory & Cognition

New Product From Metagenic’s

Discover the Neuroprotective Benefits of Huperzine A

According to the National Institutes of Health, an estimated one in four U.S. adults suffer from mental health disorders in a given year. For millions of people, this translates to complaints relating to
memory, forgetfulness, and dementia. Although these conditions are often seen as a natural consequence of the aging process, losing the ability to think, remember, and learn are NOT inevitable.

In fact, there are many effective strategies for maintaining optimal mental function, including the targeting of neurotransmitters—the endogenously produced chemicals that act as messengers between
cells in the brain. And for cognitive processing, memory, arousal, and attention—scientists have identified the neurotransmitter acetylcholine as playing a critical role. Consequently, gradual loss of
mental clarity is associated with diminishing acetylcholine synthesis and rapid degradation by the enzyme acetylcholinesterase (AChE).

Targeting Neurotransmitter Balance

As mentioned above, the primary goal of many conventional treatments for neurological health is neurotransmitter modulation. For example, current drugs for the treatment of Alzheimer’s disease (AD) exert their effects by blocking AChE and increasing synaptic acetylcholine levels. However, many doctors prefer natural and clinically successful neurological health products that are uniquely designed to act centrally—within the brain—through the careful
selection of ingredients.

The Rise of Huperzine A

One natural ingredient that has a long track record of clinical efficacy and safety in protecting the brain and improving memory/learning through acetylcholine support is purified huperzine A—an alkaloid from Chinese club moss (Huperzia serrata). In the early 1980s, a team of Chinese scientists identified a new application for Chinese club moss that was linked to this specific molecule. Today, abundant research suggests that huperzine A exerts a slow reversible
inhibition of AChE and preserves acetylcholine, resulting in the alleviation of many of the symptoms and progression of AD.* In one clinical trial, patients with Alzheimer’s disease treated with huperzine A had significant improvement in memory, cognitive, and
behavioral function scales compared to placebo after 8 weeks of treatment.*

Because of its history of success, huperzine A is currently in phase III human clinical trials in China and phase II clinical trials in the United States for the treatment of patients with Alzheimer’s disease.

The Mayo Clinic and National Institute of Mental Health are the primary participants in this U.S.-based investigation.

Another benefit of huperzine A is that it can used to support mental clarity and cognitive function in the absence of dementia or AD. Although a person with a family history of early onset senile dementia and AD may want to consider including huperzine A in their basic supplement program for brain protection—an individual who is over 40 years old and not feeling as “mentally sharp” as they used to, and those experiencing increasing forgetfulness, minor memory
lapses, and difficulty following directions may also benefit from small amounts of huperzine A as a “brain tonic.” (Menopausal women also may find huperzine A helpful).

What’s the difference between “purified huperzine A” and a standardized extract of Huperzia serrata supplying measurable levels of huperzine A?

Proof of safety and efficacy are the critical differences between purified huperzine A and the standardized extract of Huperzia serrata. There are over 300 published articles identifying the structure, function, and bioavailability, mechanism of actions,
safety, and dose response of the purified molecule called HupA with regards to neurological effects and its influence in memory, dementia, and AD. Only the purified huperzine A is the subject of current human clinical trials for AD. The operative word is “purified.”
There is no such body of useful information, based on traditional application or current science, regarding the use of a standardized extract which contains other undisclosed substances and huperzine
alkaloids, one of which is huperzine A.

More about Ceriva at http://www.healthdesigns.com/ShopSite/Meta/ceriva.html.

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These statements have not been evaluated by the Food and Drug Administration.  These products are not intended to diagnose, treat, cure, or prevent any disease.

HealthDesigns.com Newsletter
HDI eNews
Oct 12 2006
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in this issue
* New Products
* All Nutritional Products Are NOT Created Equal

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All Nutritional Products Are NOT Created Equal

Sure—they may look the same or even taste the same, and the labels are likely to contain similar (if not identical) lists of key ingredients.

Does this mean that they are all the same? Certainly not! In fact, numerous manufacturers state that their products meet or exceed all GMP (Good Manufacturing Practices) standards, but do they really?

It appears that the only objective way to determine the credibility of a manufacturer’s GMP status is to see its certification.

Why go through all that trouble? Because end-products from questionable, non-GMP-certified manufacturing processes may lead to less safe and less effective supplements for you.

Therefore, be sure to distinguish the products made by GMP-certified manufacturers, such as Metagenics, Inc., from the rest!

5 Markers of Quality in a Nutritional Supplement Company

Keep in mind that GMP deals with designing, building, and implementing advanced controls into the system to reduce the chance of:

* Product contamination
* Mix-ups
* Errors

Would you place your trust in any product—especially a nutritional supplement—that is made without these controls? Probably not. Listed below are the 5 markers of quality to look for in
manufacturers of nutraceuticals:

* GMP-Certified Manufacturing Facilities
* Comprehensive Scientific Evaluation of Ingredients.
* Comprehensive Safety Reviews.
* Human Clinical Evaluations.
* Scientific Staff and Facilities.

Keep reading at http://www.healthdesigns.com/MetagenicQuality.html

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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat,
cure, or prevent any disease.

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New Products

ImmuCore – Multidimensional Support for Immune Function
Ceralin Forte - Multidimensional Brain Support
Ceriva - Acetylcholine Function
Symphora - Brain Cortisol Function
Trancor - GABA & Glutamate Balance
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HealthDesigns.com Newsletter
HDI eNews
Oct 11 2006
in this issue
* Blood Sugar: A Balancing Act
* Medical Food Support for Blood Sugar-Related Conditions
* Nutraceutical Support for Maintaining Healthy Glucose & Insulin Function
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Blood Sugar: A Balancing Act
Questioning “Normal” Levels & Weighing Other Factors
Research has shown that poor insulin and glucose function may play a significant role in the onset of more serious health concerns, such as type 2 diabetes and cardiovascular disease (CVD).
In addition to the 20.6 million American adults with type 2 diabetes, estimates from 2002 suggest that 54 million adults also have impaired fasting glucose (IFG).* For clinical purposes, either IFG or impaired glucose tolerance (IGT) is now considered “pre-
diabetes.”
Studies have shown that many with pre-diabetes develop type 2 diabetes within 10 years, and are at a 50% greater risk of developing CVD.* A timely diagnosis is critical, because progression to diabetes from pre-diabetes is not inevitable.*
New Criteria & Associated Risk Factors
In 2003, experts recommended that the criterion for recognizing IFG be lowered from 110 mg/dL to 100 mg/dL.* Using this criterion could mean that an additional 20%—or almost 11 million more U.S. adults—have pre-diabetes. (The same IFG criterion
reduction was also made in 2005 for recognizing metabolic syndrome.*)
But according to a recent study, even blood sugar levels in the higher yet “normal” range of 87 mg/dL to 99 mg/dL may also predict diabetes risk—along with body mass index (BMI), physical activity level, smoking status, and serum triglyceride levels.* Another study suggests that an increase in BMI of 1 kg/m2 (even in the non-obese level) may raise the risk of type 2 diabetes by about 25%.*
Changing Lifestyles, Changing Lives
Experts now recognize that lifestyle changes—such as dietary changes, body composition improvement, and modest exercise—can delay or prevent the onset of type 2 diabetes by up to 58%.* In addition to a delay in onset, studies have shown that people with
pre-diabetes who improve their BMI and increase their physical activity can even return their blood glucose levels to a normal range.*
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Medical Food Support for Blood Sugar-Related Conditions
Metagenics is the medical food leader in providing clinically tested approaches to nutritionally supporting the management of a wide range of conditions related to impaired blood sugar management. These programs incorporate a low-
glycemic-index (GI) dietary plan and exercise recommendations for optimal clinical outcomes when combined with the targeted nutritional support of these science-based medical food formulas.
These formulas are available in a variety of delicious flavors to fit your tastes and make a convenient beverage at home or on the go.
Metabolic Syndrome & Associated Conditions
UltraMeal®
Medical food program
Low-GI formula designed to nutritionally support the management of conditions associated with metabolic syndrome, such as:
* Altered body composition
* Central obesity
* Insulin resistance
Patient benefits:
* Clinically tested and shown to promote the loss of fat while helping maintain lean muscle mass.
* Also available: UltraMeal® Bar medical food and whey and rice protein options.
Metabolic Syndrome & Cardiovascular Disease
UltraMeal® Plus
Medical food program
Low-GI formula designed to nutritionally support the management of conditions associated with metabolic syndrome and CVD, such as:
* Hypercholesterolemia
* Hypertriglyceridemia
* Hypertension
Patient benefits:
* Features a proprietary blend of soy protein and plant sterols in accordance with NIH
recommendations.
* Clinically tested and shown to positively influence 14 markers of cardiovascular health.
Type 2 Diabetes & Hypoglycemia
UltraGlycemX®
Medical food program
Low-GI formula designed to nutritionally support the management of conditions associated with dysglycemia, such as:
* Type 2 diabetes
* Hypoglycemia
Patient benefits:
* Supports healthy insulin and glucose metabolism.
* Protects against oxidative stress.
* Ingredients clinically tested and shown to improve insulin markers to a greater degree than following a low GI dietary plan alone.
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Nutraceutical Support for Maintaining Healthy Glucose & Insulin Function
These science-based nutraceutical options are ideal complements to a healthy diet to maintain blood
sugar homeostasis. These natural approaches have been tested in a clinical setting and provide powerful
new ways to help you on the path to maintaining health.
These formulas are available in convenient, easy-dose tablets.
Selective Kinase Response Modulators (SKRMs) Designed for Healthy Insulin Function
Insinase
A scientific breakthrough designed to promote healthy insulin sensitivity and triglyceride levels by
providing a unique, combined ratio of reduced iso-alpha acids (RIAA) and acacia extract.
Recommended uses:
* Healthy insulin function
* Healthy glucose utilization
* Healthy metabolic function
Patient benefits:
* Proprietary formula featuring SKRMs—RIAA and acacia—which have been clinically shown in a
preliminary study at the Functional Medicine Research CenterSM, the clinical research arm of
Metagenics, to improve fasting insulin and lipid parameters
* Modulates kinase signaling in adipocytes— fat-storing cells involved in glucose utilization and insulin
signaling
* Supporting healthy kinase signaling may help maintain healthy blood sugar already in the normal
range and healthy triglyceride levels
* In vitro testing of the active ingredients has demonstrated inhibition of IL-6 cytokines— which
influence insulin function
Nutritional Support for Healthy Blood Sugar
MetaGlycemX
This scientifically advanced formula features a unique combination of green tea, cinnamon, and alpha-lipoic acid—along with a foundation of nutrients that support healthy blood sugar management.
Recommended uses:
* Healthy blood sugar support
* Complement to a healthy diet
Patient benefits:
* Features green tea catechins (EGCG), to help protect the insulin-secreting pancreatic islet cells
* Supplies bioactive cinnamon compounds that may support insulin activity
* Provides alpha-lipoic acid—a free radical scavenger that may also enhance insulin sensitivity
* Delivers a sophisticated blend of targeted micronutrients and antioxidants to support healthy
glucose metabolism
*References available upon request.

HealthDesigns.com Newsletter
HDI eNews

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in this issue
* Sleep Adjustment Bed
* Men’s Health and Wellness

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Men’s Health and Wellness

Dr. Schneider at HealthDesigns.com recommends these men-specific nutraceuticals that support daily wellness, reproductive health, sexual function, and hormone balance.

Health & Wellness

Wellness Essentials for Men

Guarantees daily intake of essential vitamins,   minerals, and omega-3 fatty acids to maintain overall health.
  
* Stress response
* Sexual function
* Energy & performance
* Cardiovascular health
* Immune health

Sexual Function

Tribulus Synergy

Features traditionally used herbs known for their aphrodisiac and adaptogenic properties
  
* Libido concerns
* Sexual function
* Stress response

Sexual Performance

Arginine Plus with ActiFolate

Promotes healthy sexual performance, presumably through enhancing genital blood flow

* Sexual function
* Sexual vitality

Hormone Levels

BioSom

Provides DHEA delivered via a pleasant-tasting spray to enhance hormone levels.
 
* DHEA level concerns
* Age-related hormone changes
* Energy
* Mood & well-being
* Sexual function

Prostate Concerns

Concentrated Ultra Prostagen

Features saw palmetto and complementary
nutrients to maintain healthy prostate function.
 
* Prostate concerns
* Urinary function
* Reproductive health

Testosterone Balance

Promotes healthy levels of testosterone, while
inhibiting levels of certain hormone metabolites.

* Age-related hormone changes
* Prostate health
* Reproductive health

For more detailed info, go to www.healthdesigns.com/MensHealth.html
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These statements have not been evaluated by the
Food and Drug Administration.
These products are not intended to diagnose, treat,
cure, or prevent any disease.
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